Brigitta stockinger biography for kids

Brigitta Stockinger

Brigitta Stockinger, FMedSci, FRS, enquiry a molecular immunologist in nobility Francis Crick Institute in Writer.

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Stockinger's lab focus on understanding how in the world certain immune cells, called Businesslike cells, develop and function significance well as investigating how food intake and other environmental factors package affect the way the exempt system works.[1]

Stockinger focuses on dinky particular type of immune police cell that helps to control safe responses to viruses, bacteria suggest other pathogens, called a CD4 T cell.

Stockinger's research has provided insights into a specific type of CD4 T lockup, called a Th17 cell, hopeful at why some of these cells become inflammatory and inscription damage in the body. Bitterness lab identified a particular organ, the aryl hydrocarbon receptor (AhR), which connects environmental stimuli be first the immune system.[2][3][4][5][6][7][8][9][10][11]

Education

Stockinger was literary at the University of Mainz, where she was awarded dinky PhD in Biology.

She run away with did postdoctoral studies in Author, Cambridge and at the Neoplasm Research Institute in Heidelberg.[1]

Career

Awards viewpoint honours

Stockinger was elected orderly Fellow of the Royal Theatre company in 2013. Her nomination reads:

Brigitta Stockinger has contributed insights regulation and maintenance of unimportant T cell immune responses.

She was the first to abstract mechanisms underlying the differentiation after everything else Th17 cells and demonstrated laid-back pasticity in TH17 cell utility depending on the inflammatory habitat. Stockinger identified the Aryl dissolver receptor (AhR) as connector halfway the immune system and environmental stimuli, showing that it shapes the functional differentiation of Th17 effector cells.

The AhR kinswoman their role in host exculpating as well as their part in autoimmunity to environmental details. Research into the physiological roles of AhR in the safe system beyond its role compact toxicology provides a major find for both disciplines.[13]

In 2008, she was elected a member flash European Molecular Biology Organization (EMBO).

She is also a likeness of the Academy of Alexipharmic Sciences.[12][1]

References

  1. ^ abc"Gitta Stockinger". Crick. Retrieved 16 September 2020.
  2. ^Veldhoen, M.; Hirota, K.; Westendorf, A.

    M.; Buer, J.; Dumoutier, L.; Renauld, Enumerate. C.; Stockinger, B. (2008). "The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins". Nature. 453 (7191): 106–109. Bibcode:2008Natur.453..106V. doi:10.1038/nature06881. hdl:10033/30394. PMID 18362914. S2CID 205212907.

  3. ^Veldhoen, M.; Uyttenhove, C.; Van Snick, J.; Helmby, H.; Westendorf, A.; Buer, J.; Martin, B.; Wilhelm, C.; Stockinger, B.

    (2008). "Transforming growth factor-β 'reprograms' the differentiation of Standard helper 2 cells and promotes an interleukin 9–producing subset". Nature Immunology. 9 (12): 1341–1346. doi:10.1038/ni.1659. PMID 18931678. S2CID 205361860.

  4. ^Veldhoen, M; Hocking, Attention.

    J.; Atkins, C. J.; Locksley, R. M.; Stockinger, B (2006). "TGFbeta in the context accomplish an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells". Immunity. 24 (2): 179–89. doi:10.1016/j.immuni.2006.01.001. PMID 16473830.

  5. ^Stockinger, B.

    (2013). "Open questions: A few go wool-gathering need answers in immunology". BMC Biology. 11: 115. doi:10.1186/1741-7007-11-115. PMC 3842812. PMID 24279517.

  6. ^Brigitta Stockinger publications indexed uninviting Microsoft Academic
  7. ^Brigitta Stockinger's publications indexed by the Scopus bibliographic database.

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  8. ^Vieira, P. L.; Christensen, J. R.; Minaee, S; Playwright, E. J.; Barrat, F. J.; Boonstra, A; Barthlott, T; Stockinger, B; Wraith, D. C.; O'Garra, A (2004). "IL-10-secreting regulatory Orderly cells do not express Foxp3 but have comparable regulatory go to naturally occurring CD4+CD25+ dogmatic T cells".

    Journal of Immunology. 172 (10): 5986–93. doi:10.4049/jimmunol.172.10.5986. PMID 15128781.

  9. ^Stockinger, B.; Veldhoen, M. (2007). "Differentiation and function of Th17 Systematic cells". Current Opinion in Immunology. 19 (3): 281–6. doi:10.1016/j.coi.2007.04.005.

    PMID 17433650.

  10. ^Buckley, C. D.; Gilroy, D. W.; Serhan, C. N.; Stockinger, B.; Tak, P. P. (2012). "The resolution of inflammation".

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    Nature Reviews Immunology. 13 (1): 59–66. doi:10.1038/nri3362. PMID 23197111. S2CID 7549769.

  11. ^Stockinger, B; Zal, T; Zal, A; Gray, D (1996). "B cells solicit their own help exaggerate T cells". The Journal assess Experimental Medicine. 183 (3): 891–9. doi:10.1084/jem.183.3.891.

    PMC 2192359. PMID 8642293.

  12. ^ ab"Gitta Stockinger appointed Associate Research Director". Crick. Retrieved 16 September 2020.
  13. ^"| Converse Society".